A group of five young friends travel from Los Angeles to exotic Panama for a week of partying in lush tropical paradise. Befriending a beautiful local woman in their hotel bar, they learn of a secret jungle hike to a pristine waterfall nearby. The woman cautions them strongly against the hike, warning that other gringos in search of the legendary waterfall had mysteriously disappeared into the jungle, never to be seen or heard from again. Ignoring her warnings, the group convinces the woman to guide them to the picturesque waterfall, thinking that they have nothing to fear with a local as their guide. What begins as a fun outing quickly turns terrifying when their guide mysteriously vanishes after a romantic tryst at the falls. As night closes in, the friends realize too late the truth behind her warnings— horrific, bloodthirsty, flesh-eating creatures are now stalking them. The mangled survivors rush to jungle caves for shelter, only to realize they’ve entered the monsters’ lair!
羅德（安迪?薩姆伯格 Andy Samberg 飾）與同母異父的弟弟凱（喬瑪?塔昆 Jorma Taccone 飾），以及兩個又二又喪的朋友成了一個特技飛車小組。車手羅德的生活中只有兩事：繼承死去的特技車手親的遺志，打贏強壯的繼弗蘭克（伊恩?麥柯肖恩 Ian McShane 飾）。但羅德的所有特技演幾乎都淪為瘋狂的自毀動，而全副武裝后的每一挑戰(zhàn)結(jié)果都是被弗蘭克擊。精力超級旺盛的不死之羅德也幾乎挺不住了！可天他突然驚聞弗蘭克罹患臟病，羅德為實現(xiàn)弗蘭克死于自己之手的愿望，計進行前所未有的飛車表演為弗蘭克籌集手術(shù)款，并機將自己暗戀已久鄰家美丹妮絲（艾拉?菲舍爾 Isla Fisher 飾）拉入了隊伍。于是，一近似于自殺的飛車表演拉了無厘頭大幕…?
